Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.57 |
| ▸ | PDE4A | P27815 | 10/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2956981 | 0.93 | CSNK2A1 (0.66) | CSNK2A1PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL2371289 | 0.85 | PDE4B (0.60) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7335293 | 0.83 | PDE4A (0.58) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7324348 | 0.83 | PDE4B (0.56) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7353001 | 0.82 | KDM4E (0.66) | CSNK2A1PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL7420826 | 0.82 | PDE4A (0.57) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7088472 | 0.82 | PDE4B (0.65) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL2958828 | 0.81 | RECQL (0.60) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7023339 | 0.81 | PDE4B (0.55) | PDE4BPDE4APDE4DPDE4CMAPK14 | |
| SCHEMBL7332617 | 0.81 | PDE4B (0.58) | PDE4BPDE4APDE4DPDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0814809-B1 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 2003-08-13 | — | — | EP | disclosed |
| US-6440979-B1 | Aryl isoguanines | EURO-CELTIQUE, S.A. (LU) | 2002-08-27 | — | — | US | disclosed |
| US-6090816-A | ANTIASTHMA AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-07-18 | — | — | US | disclosed |
| US-6066641-A | PHOSPHODIESTERASES AS MOLECULAR TARGETS FOR ANTI-ASTHMATIC AGENTS | EURO-CELTIQUE S.A. (LU) | 2000-05-23 | — | — | US | disclosed |
| EP-0814809-A4 | ARYL THIOXANTHINES | EURO CELTIQUE SA (LU) | 1998-04-01 | — | — | EP | disclosed |
| EP-0814809-A1 | ARYL THIOXANTHINES | Euroceltique S.A. (LU) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996018399-A1 | ARYL THIOXANTHINES | EURO-CELTIQUE, S.A. (LU) | 1996-06-20 | — | — | WO | disclosed |