Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | THRA | P10827 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7420826 | 0.99 | PDE4A (0.57) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL5348988 | 0.92 | PDE4B (0.56) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL8157358 | 0.90 | HDAC1 (0.56) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL7324348 | 0.90 | PDE4B (0.56) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL7326412 | 0.88 | HDAC1 (0.58) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL2371289 | 0.86 | PDE4B (0.60) | PDE4APDE4BPDE4DPDE4CPOLB | |
| SCHEMBL7420231 | 0.85 | HDAC1 (0.53) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL8576115 | 0.84 | PDE4B (0.53) | PDE4APDE4BPDE4DPDE4CHDAC1 | |
| SCHEMBL31254180 | 0.84 | THRA (0.52) | HDAC1HDAC2THRATHRB | |
| SCHEMBL7327718 | 0.84 | HDAC1 (0.59) | PDE4APDE4BPDE4DPDE4CHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | claimed |
| US-5274002-A | 1-Oxy- or -thio-2-cycloalkyloxy-4-carboxyalkylene benzene derivatives | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-4971959-A | Trisubstituted phenyl analogs having activity for congestive heart failure | WARNER-LAMBERT COMPANY (US) | 1990-11-20 | — | — | US | disclosed |