Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 8/20 | 0.65 |
| ▸ | MAP2K7 | O14733 | 2/20 | 0.64 |
| ▸ | ITK | Q08881 | 3/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.55 |
| ▸ | TTK | P33981 | 1/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.53 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.53 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5372815 | 0.85 | MAP2K4 (0.56) | AURKAITKCYP2C19AURKBTTK | |
| SCHEMBL5383405 | 0.82 | TTK (0.54) | AURKAITKCYP2C19AURKBTTK | |
| SCHEMBL5374376 | 0.81 | MAPT (0.55) | AURKAITKAURKBTTKMAPK8 | |
| SCHEMBL8253366 | 0.81 | ITK (0.51) | AURKAITKCYP2C19AURKBTTK | |
| SCHEMBL23721711 | 0.80 | AURKA (0.63) | AURKAMAP2K7AURKBTTKMAPK8 | |
| SCHEMBL6501210 | 0.79 | AURKA (0.51) | AURKAITKCYP2C19AURKBTTK | |
| SCHEMBL23722543 | 0.78 | AURKA (1.00) | AURKAMAP2K7AURKBMAPK1MAP2K4 | |
| SCHEMBL7166053 | 0.77 | NLRP3 (0.57) | AURKAMAP2K7AURKBTTKMAPK1 | |
| SCHEMBL7139658 | 0.76 | CYP2C19 (0.51) | CYP2C19MAPK1CDK8KDM4ESMN1; SMN2 | |
| SCHEMBL23721799 | 0.76 | AURKA (0.71) | AURKAMAP2K7ITKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313711-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| WO-2002010137-A9 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARM INC (US) | 2003-02-06 | — | — | WO | disclosed |
| WO-2002010137-A2 | INDAZOLE DERIVATIVES AS JNK INHIBITORS | SIGNAL PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |