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Norethindrone Acetate

Norethindrone Acetate

SCHEMBL7091490

C#CC1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC.C#C[C@]1(OC(C)=O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C

nearest known ligand 0.79

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PGR

The experimentally established mechanism targets of Norethindrone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR known ✓ P06401 9/20 0.79
▸ AR P10275 7/20 0.79
▸ CYP3A4 P08684 6/20 0.79
▸ ABCB11 O95342 5/20 0.79
▸ NR3C1 P04150 4/20 0.79
▸ CYP2C19 P33261 4/20 0.79
▸ MEN1 O00255 3/20 0.79
▸ KMT2A Q03164 3/20 0.79
▸ ADORA3 P0DMS8 3/20 0.79
▸ SLC6A2 P23975 3/20 0.79
▸ MAPT P10636 2/20 0.79
▸ CHRM1 P11229 2/20 0.79
▸ ADRA1A P35348 2/20 0.79
▸ MAPK1 P28482 2/20 0.79
▸ CHRM2 P08172 1/20 0.79
▸ TBXA2R P21731 1/20 0.79
▸ LMNA P02545 6/20 0.75
▸ SLC6A4 P31645 5/20 0.75
▸ ESR1 P03372 5/20 0.75
▸ SHBG P04278 3/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Norethindrone Acetate SCHEMBL8038659 0.91 CYP3A4 (0.89) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL691854 0.91 CYP3A4 (0.89) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL14074495 0.89 CYP3A4 (1.00) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL1232662 0.89 CYP3A4 (1.00) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL14577826 0.89 CYP3A4 (1.00) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL11321479 0.89 CYP3A4 (1.00) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL14360522 0.89 CYP3A4 (1.00) PGRARCYP3A4ABCB11NR3C1
Norethindrone Acetate SCHEMBL37530 0.89 CYP3A4 (1.00) PGRARCYP3A4ABCB11NR3C1
SCHEMBL5692407 0.88 PGR (0.79) PGRARCYP3A4ABCB11NR3C1
SCHEMBL3164280 0.88 PGR (0.79) PGRARCYP3A4ABCB11NR3C1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030149008-A1 Hormonal implants treatment of the breast cancer SAHADEVAN VELAYUDHAN (US) 2003-08-07 — — US claimed
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