Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 12/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.55 |
| ▸ | CLK2 | P49760 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | STK3 | Q13188 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.54 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3578405 | 0.93 | ROCK2 (0.63) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL5737426 | 0.88 | ROCK2 (0.55) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Hydrochloric Acid SCHEMBL3585306 | 0.87 | ROCK2 (0.54) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL3590236 | 0.86 | ROCK2 (0.78) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL5737623 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL3589828 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL3588269 | 0.85 | MKNK1 (0.54) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| Hydrochloric Acid SCHEMBL3580794 | 0.85 | ROCK2 (0.52) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL3583259 | 0.83 | ROCK2 (0.64) | ROCK2ROCK1CLK2BLKCSNK2A1 | |
| SCHEMBL3589238 | 0.83 | ROCK2 (0.49) | ROCK2ROCK1CLK2BLKCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370553-A2 | RHO-KINASE INHIBITORS | Bayer Corporation (US) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002076976-A2 | RHO-KINASE INHIBITORS | BAYER CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |