Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | FNTA | P49354 | 10/20 | 0.35 |
| ▸ | FNTB | P49356 | 10/20 | 0.35 |
| ▸ | RORC | P51449 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7089905 | 0.92 | IDO1 (0.47) | IDO1FNTAFNTBRORCGSK3B | |
| SCHEMBL7092101 | 0.90 | IDO1 (0.46) | IDO1FNTAFNTBRORCMAPK1 | |
| SCHEMBL7091512 | 0.87 | IDO1 (0.43) | IDO1FNTAFNTBGSK3BDYRK1A | |
| SCHEMBL7210392 | 0.76 | IDO1 (0.52) | IDO1FNTAFNTBRORCMAPK1 | |
| SCHEMBL6556841 | 0.72 | FNTA (0.52) | IDO1FNTAFNTBMAPK1PGGT1B | |
| SCHEMBL7094385 | 0.71 | IDO1 (0.48) | IDO1FNTAFNTBRORCGSK3B | |
| SCHEMBL7095527 | 0.68 | IDO1 (0.44) | IDO1FNTAFNTBMAPK1PGGT1B | |
| SCHEMBL23539669 | 0.67 | IDO1 (1.00) | IDO1FNTAFNTBGSK3BDYRK1A | |
| SCHEMBL30042691 | 0.67 | IDO1 (1.00) | IDO1FNTAFNTBGSK3BDYRK1A | |
| SCHEMBL28532205 | 0.67 | IDO1 (0.50) | IDO1FNTAFNTBPGGT1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322635-A1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024682-A1 | FARNESYL TRANSFERASE INHIBITING QUINOLINE AND QUINAZOLINE DERIVATIVES AS FARNESYL TRANSFERASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |