Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701570 | 0.78 | CHEK1 (0.48) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7843138 | 0.76 | CHEK1 (0.52) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7091655 | 0.73 | CHEK1 (0.60) | CHEK1KDRCDK1CDK2PDGFRB | |
| SCHEMBL7704667 | 0.72 | NPC1 (0.54) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7089369 | 0.72 | CHEK1 (0.56) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7094279 | 0.72 | KDR (0.58) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL6998875 | 0.71 | CHEK1 (0.52) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7002588 | 0.71 | KDR (0.74) | CHEK1KDRCDK1CDK2PDGFRB | |
| SCHEMBL7091508 | 0.70 | KDR (0.56) | CHEK1KDRCDK1CDK2 | |
| SCHEMBL7701864 | 0.70 | CHEK1 (0.54) | CHEK1KDRCDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |