Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 15/20 | 0.54 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998707 | 0.89 | KDR (0.57) | KDRCHEK1CDK1CDK2SGK1 | |
| SCHEMBL7698769 | 0.82 | KDR (0.58) | KDRCHEK1CDK1CDK2SGK1 | |
| SCHEMBL7702162 | 0.80 | KDR (0.55) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7094279 | 0.78 | KDR (0.58) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7003449 | 0.77 | CHEK1 (0.60) | KDRCHEK1CDK1CDK2SGK1 | |
| SCHEMBL7089915 | 0.77 | CHEK1 (0.68) | KDRCHEK1CDK1CDK2SGK1 | |
| SCHEMBL7096519 | 0.76 | CHEK1 (0.64) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7701855 | 0.76 | NAMPT (0.64) | KDRCHEK1CDK1CDK2SGK1 | |
| SCHEMBL7095260 | 0.76 | CHEK1 (0.58) | KDRCHEK1CDK1CDK2 | |
| SCHEMBL7701559 | 0.76 | NAMPT (0.52) | KDRCHEK1CDK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | disclosed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | disclosed |