Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7091165 | 0.80 | KCNH2 (0.32) | KCNH2 | |
| SCHEMBL6510985 | 0.80 | PDE4B (0.33) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL22939298 | 0.75 | PTGER4 (0.39) | PTGER4CYP2A6TYRKDM4EMEN1 | |
| SCHEMBL22643923 | 0.71 | PTGER4 (0.37) | PTGER4CYP2A6TYRKDM4EALDH1A1 | |
| SCHEMBL22632878 | 0.66 | KDM4E (0.53) | KDM4E | |
| SCHEMBL35838388 | 0.66 | KDM4E (0.53) | KDM4E | |
| SCHEMBL8687281 | 0.64 | PTGER4 (0.49) | PTGER4CYP2A6TYRKDM4EMEN1 | |
| SCHEMBL28503738 | 0.64 | PTGER4 (0.49) | PTGER4CYP2A6KDM4EMEN1NPC1 | |
| SCHEMBL9231758 | 0.62 | TYR (0.52) | CYP2A6TYRKDM4EALDH1A1HPGD | |
| SCHEMBL23242341 | 0.61 | CYP2A6 (0.50) | PTGER4CYP2A6KDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268422-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | Bayer Aktiengesellschaft (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070687-A1 | INDOLES FOR TREATING DISEASES THAT CAN BE TREATED USING THYROID HORMONES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-27 | — | — | WO | disclosed |