Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9910947 | 0.81 | HSD11B1 (0.45) | HSD11B1HPGDALDH1A1PDE5AFFAR4 | |
| SCHEMBL16334324 | 0.81 | HSD11B1 (0.45) | HSD11B1HPGDALDH1A1PDE5AFFAR4 | |
| SCHEMBL12656988 | 0.79 | HSD11B1 (0.47) | HSD11B1HPGDALDH1A1PDE5AFFAR4 | |
| SCHEMBL13990506 | 0.78 | HSD11B1 (0.43) | HSD11B1HPGDALDH1A1PDE5AFFAR4 | |
| SCHEMBL14606834 | 0.78 | HSD11B1 (0.59) | HSD11B1ALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL15668834 | 0.77 | HSD11B1 (0.45) | HSD11B1HPGDALDH1A1PDE5AFFAR4 | |
| SCHEMBL15669044 | 0.77 | HSD11B1 (0.42) | HSD11B1HPGDALDH1A1PDE5AFFAR4 | |
| SCHEMBL6809103 | 0.76 | CYP1A2 (0.45) | HPGDALDH1A1SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL354086 | 0.75 | — | — | |
| SCHEMBL7710680 | 0.75 | HSD11B1 (0.44) | HSD11B1HPGDALDH1A1PDE5AFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030232994-A1 | Bicyclic thiophene derivatives and combinatorial libraries thereof | LION BIOSCIENCE AG (DE) | 2003-12-18 | — | — | US | claimed |
| US-20030232994-A1 | Bicyclic thiophene derivatives and combinatorial libraries thereof | LION BIOSCIENCE AG (DE) | 2003-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030232994-A1 | Bicyclic thiophene derivatives and combinatorial libraries thereof | CXCR2, BICRA, CXCR1 | HSD11B1 1542/4885HPGD 3319/4885ALDH1A1 928/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.