Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 4/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.54 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | P4HB | P07237 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5058436 | 0.94 | PRKDC (0.66) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3216387 | 0.92 | PRKDC (0.68) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5063516 | 0.82 | PRKDC (0.71) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7090207 | 0.82 | PRKDC (0.71) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5065314 | 0.79 | PRKDC (0.68) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5063514 | 0.79 | PRKDC (0.72) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058383 | 0.78 | PRKDC (0.51) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL21160054 | 0.76 | PRKDC (0.67) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058593 | 0.76 | PRKDC (0.67) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058525 | 0.76 | PRKDC (0.75) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |