Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 6/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.48 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6410204 | 0.99 | HTR2C (0.49) | MCHR1EHMT2EHMT1HTR2CHTR2A | |
| SCHEMBL7010009 | 0.90 | HTR2C (0.49) | HTR2CHTR2AHTR2BPOLB | |
| SCHEMBL7003036 | 0.82 | RXFP1 (0.44) | MCHR1EHMT2 | |
| SCHEMBL6408957 | 0.78 | HTR2C (0.61) | HTR2CHTR2AHTR2B | |
| SCHEMBL7755432 | 0.78 | UTS2R (0.48) | MCHR1HTR2CHTR2AHTR2BSIGMAR1 | |
| SCHEMBL25616178 | 0.76 | EHMT2 (0.66) | MCHR1EHMT2EHMT1LTA4HSIGMAR1 | |
| SCHEMBL6628800 | 0.76 | CHRNB4 (0.44) | SMN1; SMN2 | |
| SCHEMBL8351425 | 0.75 | SMN1; SMN2 (0.71) | HTR2CHTR2AHTR2BLTA4HPOLB | |
| SCHEMBL12409045 | 0.74 | SMN1; SMN2 (0.74) | HTR2CHTR2AHTR2BLTA4HPOLB | |
| SCHEMBL1929865 | 0.74 | HTR2C (0.58) | EHMT2EHMT1HTR2CHTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |