Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | TGM1 | P22735 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092826 | 0.82 | MCHR1 (0.50) | MCHR1EHMT2 | |
| SCHEMBL6410204 | 0.81 | HTR2C (0.49) | MCHR1EHMT2 | |
| SCHEMBL7005111 | 0.80 | DRD3 (0.48) | RXFP1ALDH1A1EPHX2DRD3DRD2 | |
| SCHEMBL7010009 | 0.79 | HTR2C (0.49) | — | |
| SCHEMBL7011905 | 0.77 | ALDH1A1 (0.53) | RXFP1ALDH1A1DRD3DRD2MAPT | |
| SCHEMBL1667304 | 0.75 | NSD2 (0.49) | ALDH1A1EPHX2DRD3PDE4BKMT5A | |
| SCHEMBL22118069 | 0.73 | HTR1B (0.46) | RXFP1ALDH1A1EPHX2NPC1MAPT | |
| SCHEMBL22118162 | 0.73 | EPHX2 (0.46) | RXFP1ALDH1A1EPHX2NPC1MAPT | |
| SCHEMBL1495991 | 0.73 | KDM4E (0.46) | RXFP1EPHX2DRD3DRD2 | |
| SCHEMBL3195004 | 0.73 | ALDH1A1 (0.50) | RXFP1ALDH1A1EPHX2DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |