Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL1436402 | 0.96 | KDM4E (0.53) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL7717632 | 0.96 | KDM4E (0.53) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL9696826 | 0.96 | KDM4E (0.53) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL1318239 | 0.96 | BLM (0.59) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL170524 | 0.96 | — | — | |
| Sulfuric Acid SCHEMBL28148838 | 0.96 | BLM (0.59) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL4162831 | 0.92 | BLM (0.56) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL9797137 | 0.92 | BLM (0.56) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL22127325 | 0.92 | BLM (0.56) | BLMKDM4ECYP2C19CYP2D6NPSR1 | |
| Sulfuric Acid SCHEMBL4167092 | 0.92 | BLM (0.56) | BLMKDM4ECYP2C19CYP2D6NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444590-A | Preparation method of aminoglycoside compound | 无锡富泽药业有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2003075851-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS | CELLEGY PHARMACEUTICALS, INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| US-5686463-A | Oxadiazoles useful in the treatment of senile dementia | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0438230-B1 | Indole-substituted five-membered heteroaromatic compounds | MERCK SHARP & DOHME (GB) | 1997-04-23 | — | — | EP | disclosed |
| US-5470859-A | Cognition activators for the central nervous system | BEECHAM GROUP P.L.C. (GB) | 1995-11-28 | — | — | US | disclosed |
| EP-0414394-B1 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1995-07-05 | — | — | EP | disclosed |
| US-5317103-A | Migraine treatment | MERCK SHARP & DOHME LIMITED (GB) | 1994-05-31 | — | — | US | disclosed |
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | disclosed |
| EP-0438230-A2 | Indole-substituted five-membered heteroaromatic compounds | MERCK SHARP & DOHME LTD. (GB) | 1991-07-24 | — | — | EP | disclosed |
| EP-0414394-A2 | Azabicyclic Derivatives having muscarinic receptor affinity | BEECHAM GROUP PLC (GB) | 1991-02-27 | — | — | EP | disclosed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | disclosed |