Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.43 |
| ▸ | CTPS1 | P17812 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3617306 | 0.88 | KMT2A (0.55) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3618964 | 0.88 | KMT2A (0.52) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3621420 | 0.86 | KMT2A (0.52) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3621786 | 0.85 | ALDH1A1 (0.56) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL7140715 | 0.83 | KMT2A (0.46) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3612445 | 0.80 | KMT2A (0.71) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL7134276 | 0.80 | POLB (0.45) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3617897 | 0.80 | KMT2A (0.47) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3622234 | 0.79 | KMT2A (0.45) | KMT2AMEN1POLBALDH1A1CYP2C9 | |
| SCHEMBL3613737 | 0.79 | ALDH1A1 (0.56) | KMT2AMEN1POLBALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1283831-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2003-02-19 | — | — | EP | disclosed |
| WO-2001090090-A1 | INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 | BIOVITRUM AB (SE) | 2001-11-29 | — | — | WO | disclosed |