Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 11/20 | 0.59 |
| ▸ | F2 | P00734 | 7/20 | 0.54 |
| ▸ | F9 | P00740 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.43 |
| ▸ | PROC | P04070 | 1/20 | 0.43 |
| ▸ | KLK1 | P06870 | 1/20 | 0.43 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6298709 | 0.91 | F10 (0.67) | F10PRSS1F2F9PLAU | |
| SCHEMBL7115851 | 0.86 | F10 (0.77) | F10PRSS1F2PLGPROC | |
| SCHEMBL6298682 | 0.82 | F10 (0.59) | F10PRSS1F2F9PLAU | |
| SCHEMBL6298642 | 0.80 | F10 (0.86) | F10PRSS1F2PLGPROC | |
| SCHEMBL5164209 | 0.80 | F10 (0.52) | F10PRSS1F2F9PLAU | |
| SCHEMBL7012371 | 0.79 | F10 (0.51) | F10PRSS1F2PLGPROC | |
| Acetic Acid SCHEMBL6298091 | 0.79 | F10 (0.83) | F10PRSS1F2PLGPROC | |
| SCHEMBL7006031 | 0.78 | F10 (0.52) | F10PRSS1F2PLGPROC | |
| SCHEMBL6298667 | 0.76 | F10 (0.82) | F10PRSS1F2PLGPROC | |
| SCHEMBL6807833 | 0.76 | F10 (0.73) | F10PRSS1F2PLGPROC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268413-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070678-A2 | SUBSTITUTED BIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-09-27 | — | — | WO | disclosed |