Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ALPG | P10696 | 2/20 | 0.37 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.37 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5063532 | 0.86 | PRKDC (0.55) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7094436 | 0.84 | PIK3CA (0.39) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5054855 | 0.80 | PRKDC (0.67) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058355 | 0.78 | PRKDC (0.66) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5065308 | 0.77 | PRKDC (0.68) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7093006 | 0.74 | PRKDC (0.49) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5059642 | 0.72 | PRKDC (0.71) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11921365 | 0.70 | PRKDC (0.68) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5058436 | 0.69 | PRKDC (0.66) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL5063514 | 0.68 | PRKDC (0.72) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |