Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.39 |
| ▸ | PRKDC | P78527 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.32 |
| ▸ | PIK3R5 | Q8WYR1 | 4/20 | 0.32 |
| ▸ | PIK3R3 | Q92569 | 4/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | ACACA | Q13085 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7094434 | 0.84 | PRKDC (0.44) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL7093007 | 0.77 | PRKDC (0.45) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL5063532 | 0.74 | PRKDC (0.55) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL5054855 | 0.69 | PRKDC (0.67) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL5058361 | 0.69 | L3MBTL1 (0.51) | L3MBTL3L3MBTL1ALDH1A1ACACBACACA | |
| SCHEMBL7093006 | 0.66 | PRKDC (0.49) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL5065308 | 0.66 | PRKDC (0.68) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL11921365 | 0.65 | PRKDC (0.68) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL5058355 | 0.65 | PRKDC (0.66) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC | |
| SCHEMBL5059642 | 0.62 | PRKDC (0.71) | PIK3CAPIK3CGPIK3CDPIK3CBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351946-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002020500-A2 | MATERIALS AND METHODS TO POTENTIATE CANCER TREATMENT | ICOS CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |