Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | NAMPT | P43490 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7701118 | 0.94 | KDR (0.61) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7701734 | 0.86 | CHEK1 (0.58) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7704101 | 0.86 | CHEK1 (0.57) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7704717 | 0.84 | KDR (0.55) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7702752 | 0.83 | CHEK1 (0.64) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7002937 | 0.82 | CHEK1 (0.61) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7000955 | 0.81 | KDR (0.65) | KDRCHEK1CDK1CDK2LCK | |
| SCHEMBL6998816 | 0.81 | GLA (0.55) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7701651 | 0.81 | KDM4E (0.57) | KDRCHEK1CDK1CDK2ROCK2 | |
| SCHEMBL7698438 | 0.81 | LMNA (0.58) | KDRCHEK1CDK1CDK2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289525-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Abbott GmbH & Co. KG (DE) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001087846-A2 | TRICYCLIC PYRAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | ABBOTT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG & COMPANY KOMMANDITGESELLSCHAFT (DE) | 2001-11-22 | — | — | WO | disclosed |