Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.53 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.53 |
| ▸ | EGFR | P00533 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096211 | 0.91 | KDR (0.56) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL6404884 | 0.91 | KDR (0.57) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL7009559 | 0.88 | KDR (0.58) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL7100124 | 0.88 | KDR (0.57) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL7009404 | 0.85 | KDR (0.53) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL14448818 | 0.84 | KDR (0.71) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL6322309 | 0.82 | KDR (0.50) | KDRPDGFRBEGFRFGFR1PDGFRA | |
| SCHEMBL6321545 | 0.82 | KDR (0.50) | KDRPDGFRBEGFRFGFR1PDGFRA | |
| SCHEMBL2114044 | 0.79 | KDR (0.67) | KDRPRKAA1PDGFRBPRKAA2EGFR | |
| SCHEMBL13755172 | 0.79 | KDR (0.67) | KDRPRKAA1PDGFRBPRKAA2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |