Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.56 |
| ▸ | EGFR | P00533 | 6/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 10/20 | 0.53 |
| ▸ | PRKAA2 | P54646 | 8/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.53 |
| ▸ | NEK2 | P51955 | 2/20 | 0.53 |
| ▸ | MELK | Q14680 | 2/20 | 0.53 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | PLK4 | O00444 | 2/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7100124 | 0.93 | KDR (0.57) | KDRPDGFRBEGFRERBB2PRKAA1 | |
| SCHEMBL7095008 | 0.91 | KDR (0.53) | KDRPDGFRBEGFRERBB2PRKAA1 | |
| SCHEMBL6404884 | 0.91 | KDR (0.57) | KDRPDGFRBEGFRERBB2PRKAA1 | |
| SCHEMBL7009559 | 0.88 | KDR (0.58) | KDRPDGFRBEGFRERBB2PRKAA1 | |
| SCHEMBL14448818 | 0.84 | KDR (0.71) | KDRPDGFRBEGFRPRKAA1PRKAA2 | |
| SCHEMBL6319769 | 0.82 | KDR (0.50) | KDRPDGFRBEGFRERBB2FGFR1 | |
| SCHEMBL6319763 | 0.82 | KDR (0.50) | KDRPDGFRBEGFRERBB2FGFR1 | |
| SCHEMBL6327494 | 0.81 | CHEK1 (0.46) | KDRPDGFRBEGFRPRKAA1PRKAA2 | |
| SCHEMBL7096348 | 0.78 | KDR (0.75) | KDRPDGFRBEGFRPRKAA1PRKAA2 | |
| SCHEMBL16137754 | 0.78 | KDR (0.75) | KDRPDGFRBEGFRPRKAA1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349852-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | Sugen, Inc. (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002055517-A2 | 4-(HETERO)ARYL SUBSTITUTED INDOLINONES | CUI JINGRONG (US) | 2002-07-18 | — | — | WO | disclosed |