Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1281827 | 0.85 | USP2 (0.39) | TSHRALOX15CYP4F2CYP4A11MEN1 | |
| SCHEMBL2474730 | 0.75 | USP2 (0.40) | TSHRALOX15CYP4F2CYP4A11MEN1 | |
| SCHEMBL7443750 | 0.75 | CYP4F2 (0.45) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL16542136 | 0.74 | MEN1 (0.36) | CYP4F2CYP4A11MEN1KMT2AALDH1A1 | |
| SCHEMBL2476617 | 0.74 | MEN1 (0.40) | MAPK1CYP4F2CYP4A11MEN1KMT2A | |
| SCHEMBL2604310 | 0.74 | PKM (0.46) | TSHRALOX15CYP4F2CYP4A11 | |
| SCHEMBL1274933 | 0.74 | USP2 (0.43) | TSHRALOX15CYP4F2CYP4A11ATM | |
| Ethane SCHEMBL28337271 | 0.74 | USP2 (0.43) | TSHRALOX15CYP4F2CYP4A11ATM | |
| SCHEMBL10112411 | 0.73 | CYP4F2 (0.39) | TSHRALOX15CYP4F2CYP4A11MEN1 | |
| SCHEMBL5429191 | 0.73 | KMT2A (0.45) | MEN1KMT2AATMALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286967-A1 | CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001087838-A1 | CYCLOHEXANE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 2001-11-22 | — | — | WO | disclosed |