Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.40 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 9/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.35 |
| ▸ | ATP4A | P20648 | 2/20 | 0.35 |
| ▸ | ATP4B | P51164 | 2/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7139620 | 0.90 | PTGER1 (0.39) | C5AR1BAZ2BBAZ2APTGER1ALK | |
| SCHEMBL7014634 | 0.85 | PLA2G1B (0.40) | C5AR1BAZ2BBAZ2APTGER1ALK | |
| SCHEMBL8325750 | 0.76 | ATP4A (0.38) | PTGER1CYP1A2ALDH1A1PLA2G1BATP4A | |
| SCHEMBL7011597 | 0.72 | ATP4A (0.44) | CYP1A2PLA2G1BATP4AATP4BCYP2C9 | |
| SCHEMBL7014844 | 0.69 | ATM (0.48) | PTGER1CYP1A2ALDH1A1PLA2G1BATP4A | |
| SCHEMBL7006186 | 0.69 | PLA2G1B (0.48) | CYP1A2PLA2G1BATP4AATP4BCYP2C9 | |
| SCHEMBL7013814 | 0.69 | ATP4A (0.42) | PTGER1CYP1A2ALDH1A1PLA2G1BATP4A | |
| SCHEMBL7014264 | 0.68 | PLA2G1B (0.42) | PTGER1CYP1A2PLA2G1BATP4AATP4B | |
| SCHEMBL7010500 | 0.68 | PLA2G1B (0.55) | PTGER1PLA2G1BPTGER4PTGER3PTGER2 | |
| SCHEMBL7006857 | 0.68 | PLA2G1B (0.63) | PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| CN-1158121-A | Indolizine sPLA2Inhibitors | LILLY CO ELI (US) | 1997-08-27 | — | — | CN | disclosed |