Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361095 | 0.89 | MAPT (0.45) | NOD2NOD1MEN1KMT2ASYK | |
| SCHEMBL5361079 | 0.89 | MAPT (0.45) | NOD2NOD1MEN1KMT2ASYK | |
| SCHEMBL1980013 | 0.88 | SERPINE1 (0.40) | NOD2NOD1MEN1KMT2ASYK | |
| SCHEMBL5357070 | 0.87 | NOD2 (0.38) | NOD2NOD1SYKKDM4EBRD4 | |
| SCHEMBL5356345 | 0.87 | AAK1 (0.44) | SYKSMN1; SMN2PCSK9TSHRSERPINE1 | |
| SCHEMBL5356339 | 0.87 | AAK1 (0.44) | SYKSMN1; SMN2PCSK9TSHRSERPINE1 | |
| SCHEMBL5357064 | 0.87 | NOD2 (0.38) | NOD2NOD1SYKKDM4EBRD4 | |
| SCHEMBL5357000 | 0.86 | SYK (0.40) | NOD2NOD1MEN1KMT2ASYK | |
| SCHEMBL5357004 | 0.86 | SYK (0.40) | NOD2NOD1MEN1KMT2ASYK | |
| SCHEMBL5351582 | 0.85 | SYK (0.36) | NOD2NOD1SYKPCSK9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325008-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002010169-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-07 | — | — | WO | disclosed |