Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 6/20 | 0.68 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.68 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.68 |
| ▸ | SHBG | P04278 | 2/20 | 0.68 |
| ▸ | PGR | P06401 | 2/20 | 0.68 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.68 |
| ▸ | AR | P10275 | 2/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.68 |
| ▸ | SNCA | P37840 | 2/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.68 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.68 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3908652 | 0.87 | ABCC1 (0.70) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| Estriol SCHEMBL10412523 | 0.85 | ESR1 (0.89) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| Estriol SCHEMBL6438208 | 0.85 | ESR1 (0.89) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL17515286 | 0.85 | ABCC4 (0.56) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| Estriol SCHEMBL7992695 | 0.84 | ESR1 (0.87) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL17515288 | 0.84 | ABCC1 (0.58) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| Estriol SCHEMBL345572 | 0.83 | ESR1 (0.85) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL17515287 | 0.83 | ABCC4 (0.52) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL5521870 | 0.82 | ABCC4 (0.76) | ESR1ESR2LMNACYP2C9CYP2C19 | |
| SCHEMBL2517551 | 0.82 | ABCC4 (0.76) | ESR1ESR2LMNACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775156-B1 | PHARMACEUTICAL COMPOSITIONS CONTAINING ESTRA-1,3,5(10)-TRIENE DERIVATIVES | JENAPHARM GMBH (DE) | 2003-09-03 | — | — | EP | claimed |