Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 11/20 | 0.63 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.63 |
| ▸ | PGR | P06401 | 5/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.63 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.63 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.63 |
| ▸ | AR | P10275 | 2/20 | 0.63 |
| ▸ | TNF | P01375 | 1/20 | 0.63 |
| ▸ | IL6 | P05231 | 1/20 | 0.63 |
| ▸ | GLUL | P15104 | 1/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.63 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SHBG | P04278 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL1477515 | 0.97 | HIF1A (0.64) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| Succinic Acid SCHEMBL40948 | 0.97 | HIF1A (0.64) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| SCHEMBL719929 | 0.94 | HIF1A (0.70) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| SCHEMBL2299293 | 0.93 | HIF1A (0.72) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| SCHEMBL1512721 | 0.93 | HIF1A (0.72) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| SCHEMBL13270299 | 0.93 | HIF1A (0.72) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| Succinic Acid SCHEMBL7600416 | 0.91 | HIF1A (0.66) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| Phosphoric Acid SCHEMBL1237365 | 0.90 | NR3C1 (0.65) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| Phosphoric Acid SCHEMBL5501494 | 0.90 | NR3C1 (0.67) | HIF1ANR3C1HSD17B10PGRCYP3A4 | |
| Phosphoric Acid SCHEMBL1929804 | 0.89 | NR3C1 (0.64) | HIF1ANR3C1HSD17B10PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003082251-A2 | THE EFFERVESCENT PHARMACEUTICAL DOSAGE FORM OF ESTERS AND ESTER SALTS OF 6 α METHYLPREDNISOLONE SUCCINATE, PROCEDURE FOR ITS OBTAINING AND APPLICATION | HEMOFARM KONCERN A.D. PHARMACEUTICAL AND CHEMICAL INDUSTRY (YU) | 2003-10-09 | — | — | WO | claimed |