Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.83 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955490 | 0.94 | PDE5A (0.90) | PDE5ANR3C1PDE4B | |
| SCHEMBL12551683 | 0.91 | PDE5A (0.86) | PDE5ANR3C1PDE4B | |
| SCHEMBL7005158 | 0.91 | PDE5A (1.00) | PDE5ANR3C1PDE4B | |
| SCHEMBL7956986 | 0.89 | PDE5A (0.82) | PDE5ANR3C1PDE4B | |
| SCHEMBL7958851 | 0.88 | PDE5A (0.81) | PDE5ANR3C1PDE4B | |
| SCHEMBL7947735 | 0.88 | PDE5A (0.79) | PDE5ANR3C1PDE4B | |
| SCHEMBL7947974 | 0.87 | PDE5A (0.81) | PDE5ANR3C1PDE4B | |
| SCHEMBL7947681 | 0.87 | PDE5A (0.88) | PDE5ANR3C1PDE4B | |
| SCHEMBL7955209 | 0.87 | PDE5A (0.84) | PDE5ANR3C1PDE4B | |
| SCHEMBL7961483 | 0.86 | PDE5A (0.81) | PDE5ANR3C1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1113796-A4 | FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2003-07-30 | — | — | EP | claimed |
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | claimed |
| EP-1113796-A1 | FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-07-11 | — | — | EP | claimed |
| WO-2000015222-A1 | FUSED PYRIDINE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-03-23 | — | — | WO | claimed |
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |