Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 11/20 | 0.84 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955490 | 0.93 | PDE5A (0.90) | PDE5ANR3C1PDE4B | |
| SCHEMBL12551683 | 0.92 | PDE5A (0.86) | PDE5ANR3C1PDE4B | |
| SCHEMBL7005158 | 0.91 | PDE5A (1.00) | PDE5ANR3C1PDE4B | |
| SCHEMBL7956986 | 0.88 | PDE5A (0.82) | PDE5ANR3C1PDE4B | |
| SCHEMBL7947785 | 0.88 | PDE5A (0.79) | PDE5A | |
| SCHEMBL7096587 | 0.87 | PDE5A (0.83) | PDE5ANR3C1PDE4B | |
| SCHEMBL7947974 | 0.86 | PDE5A (0.81) | PDE5ANR3C1PDE4B | |
| SCHEMBL7947681 | 0.86 | PDE5A (0.88) | PDE5ANR3C1PDE4B | |
| SCHEMBL7958851 | 0.86 | PDE5A (0.81) | PDE5ANR3C1PDE4B | |
| SCHEMBL7954877 | 0.86 | PDE5A (0.87) | PDE5ANR3C1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | claimed |
| US-6326379-B1 | ERECTILE DYSFUNCTION; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. | 2001-12-04 | — | — | US | disclosed |