Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.45 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7630561 | 0.75 | TP53 (0.45) | P2RX4BCHEKDM4ETSHRGAA | |
| SCHEMBL6151655 | 0.75 | BCHE (0.46) | BCHEKDM4EHPGDGAAMEN1 | |
| SCHEMBL11027751 | 0.72 | ASAH1 (0.46) | P2RX4BCHEKDM4ETSHRHPGD | |
| SCHEMBL4197501 | 0.71 | KDM4E (0.69) | KDM4ETSHRMEN1KMT2ANPSR1 | |
| SCHEMBL5800630 | 0.71 | KDM4E (0.69) | KDM4ETSHRMEN1KMT2ANPSR1 | |
| SCHEMBL5217325 | 0.70 | KDM4E (0.68) | KDM4ETSHRMEN1KMT2ANPSR1 | |
| SCHEMBL6559744 | 0.70 | KDM4E (0.68) | KDM4ETSHRMEN1KMT2ANPSR1 | |
| SCHEMBL23455649 | 0.70 | SMN1; SMN2 (0.54) | P2RX4BCHEGAAASAH1 | |
| SCHEMBL714625 | 0.68 | EPHX1 (0.77) | KDM4ETSHRHPGDGAAMEN1 | |
| SCHEMBL3056874 | 0.68 | KMT2A (0.71) | KDM4ETSHRHPGDGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296975-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Sugen, Inc. (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2002002551-A1 | 4-HETEROARYL-3-HETEROARYLIDENYL-2-INDOLINONES AND THEIR USE AS PROTEIN KINASE INHIBITORS | SUGEN, INC. (US) | 2002-01-10 | — | — | WO | disclosed |