Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Ethylenediamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA3 | P07451 | 2/20 | 0.33 |
| ▸ | CA4 | P22748 | 2/20 | 0.33 |
| ▸ | CA6 | P23280 | 2/20 | 0.33 |
| ▸ | CA5A | P35218 | 2/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.33 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.33 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL1450484 | 1.00 | NFKB1 (0.36) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL440459 | 0.94 | NFKB1 (0.40) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL8214834 | 0.94 | — | — | |
| Ethylenediamine SCHEMBL1450120 | 0.88 | NFKB1 (0.36) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL5462840 | 0.88 | NFKB1 (0.36) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL17841696 | 0.88 | NFKB1 (0.36) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL3145323 | 0.88 | NFKB1 (0.36) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL28250723 | 0.88 | — | — | |
| Ethylenediamine SCHEMBL3148612 | 0.88 | NFKB1 (0.36) | NFKB1TSHRCA12CA1CA2 | |
| Ethylenediamine SCHEMBL5083587 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020012976-A1 | METHOD OF PRODUCING A TAXANE-TYPE DITERPENE AND A METHOD OF OBTAINING CULTURED CELLS WHICH PRODUCE THE TAXANE-TYPE DILTERPENE AT A HIGH RATE | YUKIMUNE YUKIHITO (JP) | 2002-01-31 | — | — | US | claimed |
| EP-1063299-A2 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | Mitsui Chemicals, Inc. (JP) | 2000-12-27 | — | — | EP | claimed |
| EP-1063300-A2 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | Mitsui Chemicals, Inc. (JP) | 2000-12-27 | — | — | EP | claimed |
| EP-1054065-A1 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | Mitsui Chemicals, Inc. (JP) | 2000-11-22 | — | — | EP | claimed |
| US-5637484-A | CULTURING TISSUES OR CELLS OF PLANT BELONGING TO GENUS TAXUS IN PRESENCE OF JASMONIC ACID, RECOVERING TAXANE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-06-10 | — | — | US | claimed |
| EP-0683232-A1 | PROCESS FOR PRODUCING TAXANE DITERPENE AND METHOD OF HARVESTING CULTRED CELL CAPABLE OF PRODUCING TAXANE DITERPENE IN HIGH YIELD | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-22 | — | — | EP | claimed |
| EP-1348764-A1 | A Method of Producing a Taxane-Type Diterpene and Method of Obtaining Cultured Cells which Produce the Taxane-Type Diterpene at a High Rate | Mitsui Chemicals, Inc. (JP) | 2003-10-01 | — | — | EP | disclosed |
| EP-1063300-B1 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | MITSUI CHEMICALS INC (JP) | 2003-09-03 | — | — | EP | disclosed |
| EP-1054065-B1 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | MITSUI CHEMICALS INC (JP) | 2002-07-31 | — | — | EP | disclosed |
| US-6403343-B2 | PLANT EXTRACT | MITSUI CHEMICALS, INC. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-20020012976-A1 | METHOD OF PRODUCING A TAXANE-TYPE DITERPENE AND A METHOD OF OBTAINING CULTURED CELLS WHICH PRODUCE THE TAXANE-TYPE DILTERPENE AT A HIGH RATE | YUKIMUNE YUKIHITO (JP) | 2002-01-31 | — | — | US | disclosed |
| EP-1063300-A2 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | Mitsui Chemicals, Inc. (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-1063299-A2 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | Mitsui Chemicals, Inc. (JP) | 2000-12-27 | — | — | EP | disclosed |
| EP-1054065-A1 | A method of producing a taxane-type diterpene and method of obtaining cultured cells which produce the taxane-type diterpene at a high rate | Mitsui Chemicals, Inc. (JP) | 2000-11-22 | — | — | EP | disclosed |
| US-5968789-A | CULTURING TISSUES OR CELLS OF PLANT FROM GENUS TAXUS IN NUTRIENT MEDIUM AND IN CONTACT WITH GAS HAVING OXYGEN AND 0.1 TO 5% CARBON DIOXIDE, RECOVERING COMPOUND FROM CULTURE | MITSUI CHEMICALS, LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| US-5637484-A | CULTURING TISSUES OR CELLS OF PLANT BELONGING TO GENUS TAXUS IN PRESENCE OF JASMONIC ACID, RECOVERING TAXANE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1997-06-10 | — | — | US | disclosed |
| EP-0683232-A1 | PROCESS FOR PRODUCING TAXANE DITERPENE AND METHOD OF HARVESTING CULTRED CELL CAPABLE OF PRODUCING TAXANE DITERPENE IN HIGH YIELD | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1995-11-22 | — | — | EP | disclosed |
| US-4615777-A | Method and composition for reducing the voltage in an electrolytic cell | OLIN CORPORATION (US) | 1986-10-07 | — | — | US | disclosed |