Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | PLAAT3 | P53816 | 3/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.54 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.54 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.54 |
| ▸ | FPR2 | P25090 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097647 | 1.00 | KMT2A (0.60) | KMT2ANPC1GAARAB9ATAAR1 | |
| SCHEMBL7101421 | 0.89 | KMT2A (0.51) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL7101423 | 0.89 | KMT2A (0.51) | KMT2ANPC1RAB9AMEN1SMN1; SMN2 | |
| SCHEMBL7099460 | 0.86 | KMT2A (0.60) | KMT2ANPC1GAARAB9ATAAR1 | |
| SCHEMBL7099462 | 0.86 | KMT2A (0.60) | KMT2ANPC1GAARAB9ATAAR1 | |
| SCHEMBL7102745 | 0.86 | KMT2A (0.57) | KMT2ANPC1GAARAB9ATAAR1 | |
| SCHEMBL7102740 | 0.86 | KMT2A (0.57) | KMT2ANPC1GAARAB9ATAAR1 | |
| SCHEMBL7098762 | 0.82 | MMP8 (0.58) | KMT2ANPC1RAB9A | |
| SCHEMBL7098758 | 0.82 | MMP8 (0.58) | KMT2ANPC1RAB9A | |
| SCHEMBL13073347 | 0.80 | KMT2A (0.63) | KMT2ANPC1GAARAB9ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |