Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.71 |
| ▸ | TEK | Q02763 | 17/20 | 0.71 |
| ▸ | RAF1 | P04049 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017823 | 0.91 | KDR (0.62) | KDRTEKRAF1 | |
| SCHEMBL5341745 | 0.91 | KDR (0.86) | KDRTEKRAF1 | |
| SCHEMBL7012448 | 0.89 | TEK (0.74) | KDRTEKRAF1 | |
| SCHEMBL7101462 | 0.87 | KDR (0.56) | KDRTEKRAF1 | |
| SCHEMBL7101458 | 0.87 | KDR (0.56) | KDRTEKRAF1 | |
| SCHEMBL5341546 | 0.84 | KDR (0.73) | KDRTEKRAF1 | |
| SCHEMBL5346580 | 0.84 | TEK (0.77) | KDRTEKRAF1 | |
| Hydrochloric Acid SCHEMBL5353541 | 0.83 | KDR (0.72) | KDRTEKRAF1 | |
| SCHEMBL5341538 | 0.81 | KDR (0.71) | KDRTEKRAF1 | |
| SCHEMBL5343526 | 0.81 | TEK (0.87) | KDRTEKRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |