Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.56 |
| ▸ | TEK | Q02763 | 13/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MYOC | Q99972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101462 | 1.00 | KDR (0.56) | KDRTEKMEN1MAPTKMT2A | |
| SCHEMBL5346740 | 0.92 | TEK (0.68) | KDRTEKMEN1MAPTKMT2A | |
| SCHEMBL7103564 | 0.90 | MAPT (0.51) | KDRTEKMEN1MAPTKMT2A | |
| SCHEMBL7103567 | 0.90 | MAPT (0.51) | KDRTEKMEN1MAPTKMT2A | |
| SCHEMBL7097972 | 0.87 | KDR (0.71) | KDRTEKRAF1 | |
| SCHEMBL7017823 | 0.87 | KDR (0.62) | KDRTEKMAPTRAF1NPC1 | |
| SCHEMBL7101422 | 0.86 | MEN1 (0.54) | KDRTEKMEN1MAPTKMT2A | |
| SCHEMBL7101420 | 0.86 | MEN1 (0.54) | KDRTEKMEN1MAPTKMT2A | |
| SCHEMBL7012448 | 0.84 | TEK (0.74) | KDRTEKRAF1 | |
| SCHEMBL5347951 | 0.84 | KDR (0.57) | KDRTEKMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |