Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | TEK | Q02763 | 8/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SAE1 | Q9UBE0 | 4/20 | 0.43 |
| ▸ | UBA2 | Q9UBT2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5346091 | 0.92 | KDR (0.61) | KDRTEKPDGFRARAF1 | |
| Hydrochloric Acid SCHEMBL5347963 | 0.91 | KDR (0.60) | KDRTEKPDGFRARAF1 | |
| SCHEMBL14375537 | 0.85 | KDR (0.70) | KDRTEKRAF1 | |
| SCHEMBL7007937 | 0.82 | KDR (0.56) | KDRTEKKMT2AMAPTPDGFRA | |
| SCHEMBL5346551 | 0.81 | TEK (0.74) | KDRTEKRAF1 | |
| SCHEMBL5357878 | 0.80 | KDR (0.69) | KDRTEKPDGFRARAF1 | |
| SCHEMBL7013365 | 0.79 | KDR (0.58) | KDRTEKMAPTSAE1UBA2 | |
| SCHEMBL7102856 | 0.78 | MEN1 (0.47) | KDRTEKKMT2APDGFRAMEN1 | |
| SCHEMBL5346888 | 0.78 | KDR (0.65) | KDRTEKMAPTGRIK1RAF1 | |
| SCHEMBL7099970 | 0.78 | MEN1 (0.47) | KDRTEKKMT2APOLBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |