Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.58 |
| ▸ | TEK | Q02763 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 6/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.51 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.51 |
| ▸ | CDK8 | P49336 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5352526 | 0.92 | KDR (0.60) | KDRTEKNPC1MAPTGAA | |
| SCHEMBL5349903 | 0.92 | KDR (0.71) | KDRTEKNPC1MAPTMAPK14 | |
| SCHEMBL7017029 | 0.90 | KDR (0.65) | KDRTEKMAPTMAPK14TNNI3K | |
| SCHEMBL5466701 | 0.90 | KDR (0.57) | KDRTEKNPC1MAPTGAA | |
| SCHEMBL7017943 | 0.89 | KDR (0.71) | KDRTEKMAPK14TNNI3KBRAF | |
| SCHEMBL5466696 | 0.84 | MAPT (0.55) | KDRTEKNPC1MAPTGAA | |
| SCHEMBL7020344 | 0.82 | TEK (0.72) | KDRTEKMAPTGAAMAPK14 | |
| SCHEMBL5349168 | 0.81 | TEK (0.79) | KDRTEKCDK8 | |
| SCHEMBL5357494 | 0.81 | KDR (0.86) | KDRTEKMAPK14TNNI3KBRAF | |
| SCHEMBL5348189 | 0.80 | TEK (0.88) | KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | claimed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | claimed |
| EP-1341771-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-09-10 | — | — | EP | disclosed |
| WO-2002044156-A2 | BENZIMIDAZOLE DERIVATIVES USEFUL AS TIE-2 AND/OR VEGFR-2 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2002-06-06 | — | — | WO | disclosed |