Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 20/20 | 0.63 |
| ▸ | KCNJ11 | Q14654 | 20/20 | 0.63 |
| ▸ | ABCC8 | Q09428 | 16/20 | 0.63 |
| ▸ | KCNJ8 | Q15842 | 16/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099014 | 0.93 | ABCC9 (0.66) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7843620 | 0.92 | ABCC9 (0.57) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL4255043 | 0.89 | ABCC9 (0.63) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL4255040 | 0.89 | ABCC9 (0.63) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7842385 | 0.86 | ABCC9 (0.76) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7097037 | 0.86 | ABCC9 (0.76) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7098168 | 0.84 | ABCC9 (0.66) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7103543 | 0.84 | ABCC9 (0.76) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7095749 | 0.84 | ABCC9 (0.62) | ABCC9KCNJ11ABCC8KCNJ8 | |
| SCHEMBL7097012 | 0.83 | ABCC9 (0.60) | ABCC9KCNJ11ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1278746-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | Abbott Laboratories (US) | 2003-01-29 | — | — | EP | disclosed |
| WO-2001083480-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-11-08 | — | — | WO | disclosed |
| EP-1131322-A2 | DIHYDROPYRIDINE COMPOUNDS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000024741-A2 | DIHYDROPYRIDINE COMPOUNDS AND THEIR USE AS POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2000-05-04 | — | — | WO | disclosed |