Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.61 |
| ▸ | ACE | P12821 | 2/20 | 0.56 |
| ▸ | CPA1 | P15085 | 2/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.56 |
| ▸ | MMP8 | P22894 | 1/20 | 0.54 |
| ▸ | ANPEP | P15144 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | FCER2 | P06734 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099566 | 1.00 | MME (0.61) | MMEACECPA1ACE2MMP8 | |
| SCHEMBL7102697 | 0.85 | MME (0.58) | MMEACECPA1ACE2MMP8 | |
| SCHEMBL7102694 | 0.85 | MME (0.58) | MMEACECPA1ACE2MMP8 | |
| SCHEMBL7102264 | 0.83 | MMP8 (0.58) | MMEACECPA1ACE2MMP8 | |
| SCHEMBL7102259 | 0.83 | MMP8 (0.58) | MMEACECPA1ACE2MMP8 | |
| SCHEMBL7098757 | 0.82 | MME (0.55) | MMEACECPA1ACE2CYP3A4 | |
| SCHEMBL7098121 | 0.82 | MME (0.55) | MMEACECPA1ACE2CYP3A4 | |
| SCHEMBL7102726 | 0.82 | MMP8 (0.54) | MMP8ANPEPALDH1A1CYP3A4MMP1 | |
| SCHEMBL7102729 | 0.82 | MMP8 (0.54) | MMP8ANPEPALDH1A1CYP3A4MMP1 | |
| SCHEMBL7098130 | 0.81 | MME (0.53) | MMEACECPA1ACE2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | claimed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | claimed |
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |