Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7788579 | 0.89 | MMP8 (0.46) | NPC1ALDH1A1MEN1KMT2AMMP8 | |
| SCHEMBL28964384 | 0.85 | HTT (0.41) | HTTMAPTGAATRPV1NPC1 | |
| SCHEMBL22125737 | 0.85 | HTT (0.41) | HTTMAPTGAATRPV1NPC1 | |
| SCHEMBL9052329 | 0.84 | MMP8 (0.50) | MAPTGAATRPV1NPC1ALDH1A1 | |
| SCHEMBL30264834 | 0.84 | KMT2A (0.48) | NPC1AOC3MEN1KMT2AHPGD | |
| SCHEMBL29116766 | 0.84 | TDP1 (0.45) | HTTMAPTALDH1A1AOC3MMP8 | |
| SCHEMBL4234045 | 0.84 | KMT2A (0.48) | NPC1AOC3MEN1KMT2AHPGD | |
| SCHEMBL28825411 | 0.83 | MAPT (0.44) | MAPTGAATRPV1NPC1ALDH1A1 | |
| SCHEMBL20839665 | 0.83 | CPN1 (0.46) | MAPTNPC1ALDH1A1MEN1KMT2A | |
| SCHEMBL16322386 | 0.83 | PSEN1 (0.49) | MAPTGAATRPV1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315490-A2 | A METHOD FOR TREATING ALLERGIES USING SUBSTITUTED PYRAZOLES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002020011-A2 | A METHOD FOR TREATING ALLERGIES USING SUBSTITUTED PYRAZOLES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-14 | — | — | WO | disclosed |