Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6730154 | 0.89 | TRPA1 (0.43) | TRPA1KDM4EMAPTUSP2ALDH1A1 | |
| SCHEMBL6730309 | 0.88 | KMT2A (0.42) | TRPA1KDM4EMAPTUSP2ALDH1A1 | |
| SCHEMBL6727645 | 0.85 | TRPA1 (0.40) | TRPA1KDM4EMAPTUSP2ALDH1A1 | |
| SCHEMBL6736766 | 0.85 | TRPA1 (0.41) | TRPA1KDM4EMAPTUSP2ALDH1A1 | |
| SCHEMBL6724877 | 0.83 | KMT2A (0.45) | TRPA1KDM4EKMT2ASMN1; SMN2TP53 | |
| SCHEMBL6529705 | 0.82 | TSHR (0.53) | TRPA1KDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL6724911 | 0.82 | KMT2A (0.42) | TRPA1KDM4EMAPTUSP2ALDH1A1 | |
| SCHEMBL6235401 | 0.82 | KDM4E (0.54) | TRPA1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL6724731 | 0.82 | TRPA1 (0.41) | TRPA1KDM4EMAPTALDH1A1HPGD | |
| SCHEMBL6735401 | 0.82 | TRPA1 (0.42) | TRPA1KDM4EMAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370562-A1 | THIENO[2,3-D]PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-17 | — | — | EP | claimed |
| WO-2002064598-A1 | THIENO'2,3-D PYRIMIDINDIONE DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | claimed |