Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.44 |
| ▸ | MLYCD | O95822 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | RORA | P35398 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | RORB | Q92753 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9861396 | 0.82 | PDE2A (0.34) | SMN1; SMN2MLYCD | |
| SCHEMBL5958755 | 0.82 | PDE2A (0.34) | SMN1; SMN2MLYCD | |
| SCHEMBL9861579 | 0.82 | PDE2A (0.44) | MEN1TSHRMAPK1KMT2AHSD17B10 | |
| SCHEMBL7101194 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2NR1H2NR1H3MLYCDMEN1 | |
| SCHEMBL4609823 | 0.77 | SMN1; SMN2 (0.48) | SMN1; SMN2NR1H2NR1H3MLYCDMEN1 | |
| SCHEMBL24408946 | 0.77 | PDE2A (0.53) | NR1H2NR1H3MLYCDMEN1ALOX15 | |
| SCHEMBL7641269 | 0.76 | RORC (0.46) | MEN1ALOX15TSHRKMT2AHSD17B10 | |
| SCHEMBL30107708 | 0.76 | RORC (0.46) | MEN1ALOX15TSHRKMT2AHSD17B10 | |
| SCHEMBL13974436 | 0.76 | SMN1; SMN2 (0.41) | SMN1; SMN2NR1H2NR1H3MLYCDMEN1 | |
| SCHEMBL11371728 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2NR1H2NR1H3MLYCDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003106435-A1 | FUSED-RING PYRIMIDIN-4(3H)-ONE DERIVATIVES, PROCESSES FOR THE PREPARATION AND USES THEREOF | SANKYO COMPANY, LIMITED (JP) | 2003-12-24 | — | — | WO | disclosed |