Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 15/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201161 | 0.82 | TGFBR1 (0.38) | METAP2CYP2A6CCR1CCR8TGFBR1 | |
| SCHEMBL411345 | 0.80 | CYP2A6 (0.35) | METAP2CYP2A6CCR1CCR8TGFBR1 | |
| SCHEMBL2047167 | 0.80 | TGFBR1 (0.41) | CYP2A6TGFBR1MAPK14CYP2D6CYP2C9 | |
| SCHEMBL6792464 | 0.77 | TGFBR1 (0.53) | TGFBR1MAPK14 | |
| SCHEMBL6757515 | 0.77 | TGFBR1 (0.59) | TGFBR1MAPK14CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL6761612 | 0.77 | KDM4E (0.43) | TGFBR1MAPK14CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL413574 | 0.69 | PIK3CD (0.45) | METAP2TGFBR1MAPK14CYP2D6 | |
| SCHEMBL11990860 | 0.69 | CCR1 (0.68) | METAP2CYP2A6CCR1CCR8TGFBR1 | |
| SCHEMBL2044546 | 0.68 | TGFBR1 (0.53) | TGFBR1MAPK14 | |
| SCHEMBL411466 | 0.68 | TGFBR1 (0.43) | METAP2CCR1CCR8TGFBR1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335916-A1 | PYRIDYL-SUBSTITUTED TRIAZOLES AS TGF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002040476-A1 | PYRIDYL-SUBSTITUTED TRIAZOLES AS TGF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-05-23 | — | — | WO | disclosed |