Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 12/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | TCF4 | P15884 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5953152 | 0.86 | ACHE (0.59) | ACHEABCB1DRD2HTR1A | |
| SCHEMBL5951741 | 0.83 | ACHE (0.49) | ACHEABCB1 | |
| SCHEMBL5951589 | 0.82 | ABCB1 (0.50) | ACHEABCB1HTR2ADRD2HTR1A | |
| SCHEMBL5952900 | 0.82 | ACHE (0.48) | ACHEABCB1 | |
| SCHEMBL5953021 | 0.82 | ABCB1 (0.50) | ACHEABCB1HTR2ADRD2HTR1A | |
| SCHEMBL5952643 | 0.81 | ACHE (0.51) | ACHEABCB1HTR2AHTR2CHTR2B | |
| SCHEMBL5952725 | 0.81 | ACHE (0.58) | ACHEHTR2AHTR2CDRD2 | |
| SCHEMBL5951611 | 0.81 | ACHE (0.47) | ACHEABCB1DRD2 | |
| SCHEMBL5951920 | 0.79 | ABCB1 (0.47) | ACHEABCB1 | |
| SCHEMBL5951777 | 0.79 | ABCB1 (0.47) | ACHEABCB1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9416139-B2 | Spiro ring compound as hepatitis C virus (HCV) inhibitor and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-08-16 | — | — | US | disclosed |
| EP-0769940-B1 | INDENE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6214876-B1 | PHOSPHOLIPASE INHIBITORS | ELI LILLY AND COMPANY | 2001-04-10 | — | — | US | disclosed |
| EP-0769940-A4 | — | — | 1997-06-11 | — | — | EP | disclosed |
| EP-0769940-A1 | INDENE sPLA 2? INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996003120-A1 | INDENE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |