Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TOP2A | P11388 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21074719 | 0.92 | KDM4E (0.68) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL29350842 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL10809240 | 0.89 | KDM4E (1.00) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL17769382 | 0.88 | KDM4E (0.62) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL6708754 | 0.87 | KDM4E (0.80) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8983611 | 0.87 | KDM4E (0.78) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL17769255 | 0.87 | KDM4E (0.60) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL825059 | 0.85 | KDM4E (0.92) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL18922404 | 0.85 | KDM4E (0.69) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL9734106 | 0.84 | KDM4E (0.57) | KDM4EALDH1A1LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282603-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF QUINOLONE DERIVATIVES | Natco Pharma Limited (IN) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001085692-A2 | AN IMPROVED PROCESS FOR THE PREPARATION OF QUINOLONE DERIVATIVES | NATCO PHARMA LIMITED (IN) | 2001-11-15 | — | — | WO | disclosed |