Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4134044 | 1.00 | TOP2A (0.55) | TOP2AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL8028311 | 0.88 | TOP2A (0.51) | TOP2AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL4395475 | 0.86 | CA12 (0.56) | TOP2AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL1535310 | 0.86 | CA12 (0.56) | TOP2AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL4137665 | 0.85 | ALDH1A1 (0.65) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL4137658 | 0.85 | ALDH1A1 (0.65) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL20085755 | 0.82 | TOP2A (0.57) | TOP2AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL4129512 | 0.80 | EPHX2 (0.66) | TOP2AALDH1A1KDM4EKMT2AMAPT | |
| SCHEMBL13777352 | 0.80 | SMN1; SMN2 (0.61) | ALDH1A1KDM4ESMN1; SMN2KMT2AMAPT | |
| SCHEMBL4129510 | 0.80 | EPHX2 (0.66) | TOP2AALDH1A1KDM4EKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339665-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | Nicox S.A. (FR) | 2003-09-03 | — | — | EP | disclosed |
| WO-2002030866-A1 | NITRODERIVATIVES AS DRUGS FOR DISEASES HAVING AN INFLAMMATORY BASIS | NICOX S.A. (FR) | 2002-04-18 | — | — | WO | disclosed |