Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 8/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.55 |
| ▸ | IKBKB | O14920 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089258 | 0.84 | CAMKK2 (0.68) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL27576337 | 0.77 | CAMKK2 (0.70) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL5092014 | 0.75 | CAMKK2 (0.66) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL5100369 | 0.74 | CAMKK2 (0.60) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL27576335 | 0.73 | CAMKK2 (0.61) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL5089234 | 0.73 | DYRK1A (0.64) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5092238 | 0.72 | CAMKK2 (0.60) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL5089194 | 0.71 | CLK4 (0.58) | CAMKK2MAPK8PIK3CGGSK3BMAPK10 | |
| SCHEMBL5089145 | 0.71 | CAMKK2 (0.55) | CAMKK2MAPK8PIK3CGIKBKBGSK3B | |
| SCHEMBL5092092 | 0.70 | CLK4 (0.69) | CAMKK2MAPK8PIK3CGIKBKBMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |