Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.52 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.52 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.52 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.52 |
| ▸ | DTYMK | P23919 | 4/20 | 0.66 |
| ▸ | DNMT1 | P26358 | 8/20 | 0.54 |
| ▸ | DNMT3B | Q9UBC3 | 4/20 | 0.54 |
| ▸ | FPR2 | P25090 | 3/20 | 0.54 |
| ▸ | DPP4 | P27487 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.52 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.52 |
| ▸ | GAPDH | P04406 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | STAT6 | P42226 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL6863617 | 0.92 | DTYMK (0.76) | DTYMKDNMT1DNMT3BFPR2DPP4 | |
| Adenosine SCHEMBL531208 | 0.92 | DTYMK (0.76) | DTYMKDNMT1DNMT3BFPR2DPP4 | |
| Adenosine SCHEMBL8846731 | 0.91 | DTYMK (0.69) | DTYMKDNMT1DNMT3BFPR2DPP4 | |
| Adenosine SCHEMBL1549514 | 0.90 | DTYMK (0.66) | DTYMKDNMT1DNMT3BFPR2DPP4 | |
| Adenosine SCHEMBL23835231 | 0.87 | DTYMK (0.66) | DTYMKDNMT1DNMT3BFPR2DPP4 | |
| Deoxyadenosine SCHEMBL20819422 | 0.86 | DTYMK (0.67) | DTYMKDNMT1DNMT3BFPR2SMN1; SMN2 | |
| Adenosine SCHEMBL17363794 | 0.85 | ADORA3 (0.72) | DNMT1DNMT3BDPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL192733 | 0.84 | ADORA3 (0.63) | DTYMKDNMT1DNMT3BFPR2DPP4 | |
| Guanosine SCHEMBL28215356 | 0.83 | F2 (0.60) | DTYMKDNMT1DNMT3BFPR2F2 | |
| Guanosine SCHEMBL11023852 | 0.83 | DTYMK (0.61) | DTYMKDNMT1DNMT3BFPR2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500066-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185704-A2 | DETECTION SYSTEM FOR ANALYZING MOLECULAR INTERACTIONS, PRODUCTION AND UTILIZATION THEREOF | Phylos, Inc. (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000071749-A2 | DETECTION SYSTEM FOR ANALYZING MOLECULAR INTERACTIONS, PRODUCTION AND UTILIZATION THEREOF | XZILLION GMBH & CO. KG (DE) | 2000-11-30 | — | — | WO | claimed |