SCHEMBL7101832

SCHEMBL7101832

C#Cc1cncc([C@H]2CCCN(NC)C2)c1

nearest known ligand 0.55

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 6/20 0.55
CHRNB4 P30926 5/20 0.55
CHRNB2 P17787 5/20 0.55
CHRNA4 P43681 4/20 0.55
CHRNA1 P02708 3/20 0.55
CHRNG P07510 1/20 0.55
CHRNB1 P11230 1/20 0.55
CHRND Q07001 1/20 0.55
CHRNA2 Q15822 1/20 0.55
DRD2 P14416 5/20 0.42
DRD3 P35462 4/20 0.42
DRD1 P21728 1/20 0.42
DRD4 P21917 1/20 0.42
DRD5 P21918 1/20 0.42
CYP2D6 P10635 1/20 0.32
TSHR P16473 1/20 0.32
NFKB1 P19838 1/20 0.32
CASP1 P29466 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7102428 1.00 CHRNA3 (0.55) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7103951 0.96 CHRNA3 (0.51) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7099486 0.96 CHRNA3 (0.51) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7099212 0.92 CHRNA3 (0.54) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7101149 0.92 CHRNA3 (0.54) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7102434 0.90 CHRNA3 (0.59) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7102601 0.90 CHRNA3 (0.59) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7098422 0.87 DRD3 (0.45) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7099140 0.84 DRD3 (0.41) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1
SCHEMBL7102539 0.84 DRD3 (0.41) CHRNA3CHRNB4CHRNB2CHRNA4CHRNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed