Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 7/20 | 0.50 |
| ▸ | CTSS | P25774 | 3/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.43 |
| ▸ | PTPRA | P18433 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL506750 | 0.85 | CTSK (0.55) | CTSKCTSSCAPN1TDP1EPHX1 | |
| SCHEMBL21561570 | 0.85 | CTSK (0.55) | CTSKCTSSCAPN1TDP1EPHX1 | |
| SCHEMBL506749 | 0.85 | CTSK (0.55) | CTSKCTSSCAPN1TDP1EPHX1 | |
| SCHEMBL7346299 | 0.85 | CAPN1 (0.50) | CTSKCTSSCAPN1TDP1MEN1 | |
| SCHEMBL10704556 | 0.82 | CTSK (0.60) | CTSKCTSSCAPN1TDP1EPHX1 | |
| SCHEMBL10481480 | 0.82 | CTSK (0.60) | CTSKCTSSCAPN1TDP1EPHX1 | |
| SCHEMBL20542796 | 0.82 | CTSK (0.70) | CTSKCTSSCAPN1TDP1MEN1 | |
| SCHEMBL20542797 | 0.82 | CTSK (0.70) | CTSKCTSSCAPN1TDP1MEN1 | |
| SCHEMBL24072863 | 0.81 | CTSK (0.54) | CTSKCTSSCAPN1TDP1EPHX1 | |
| SCHEMBL178408 | 0.81 | TDP1 (0.70) | TDP1MEN1GAAKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |