Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ANPEP | P15144 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099866 | 1.00 | KMT2A (0.51) | KMT2AMEN1TSHRCYP2C9CYP2C19 | |
| SCHEMBL7099870 | 1.00 | KMT2A (0.51) | KMT2AMEN1TSHRCYP2C9CYP2C19 | |
| SCHEMBL7102063 | 0.87 | KMT2A (0.49) | KMT2AMEN1TSHRCYP2C9CYP2C19 | |
| SCHEMBL7102068 | 0.87 | KMT2A (0.49) | KMT2AMEN1TSHRCYP2C9CYP2C19 | |
| SCHEMBL7097755 | 0.84 | MMP8 (0.54) | KMT2AMEN1TSHRPOLBRAB9A | |
| SCHEMBL7104285 | 0.84 | MMP8 (0.52) | KMT2AMEN1TSHRPOLBRAB9A | |
| SCHEMBL7104280 | 0.84 | MMP8 (0.52) | KMT2AMEN1TSHRPOLBRAB9A | |
| SCHEMBL7097759 | 0.84 | MMP8 (0.54) | KMT2AMEN1TSHRPOLBRAB9A | |
| SCHEMBL7102221 | 0.82 | POLB (0.49) | KMT2AMEN1TSHRCYP2C9CYP2C19 | |
| SCHEMBL7098602 | 0.82 | KMT2A (0.55) | KMT2AMEN1TSHRCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |