Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.58 |
| ▸ | JAK3 | P52333 | 1/20 | 0.58 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019590 | 1.00 | LCK (0.72) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7014589 | 0.93 | LCK (0.77) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7017566 | 0.90 | LCK (0.73) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7015311 | 0.89 | LCK (0.71) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7019394 | 0.88 | LCK (0.70) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7022018 | 0.88 | LCK (0.72) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7021252 | 0.87 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7592839 | 0.87 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7021167 | 0.87 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7017517 | 0.87 | LCK (0.73) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | claimed |